scientist looking at vile
PRISM™ Platform

Building the leading RNA medicines company

Our RNA medicines platform, PRISMTM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders.

vile filling

What is an “RNA medicine”?

An RNA medicine is a short strand of synthetic ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) connected by chemical linkages (also referred to as an oligonucleotide). Wave’s oligonucleotides are designed to engage messenger RNA (mRNA) strands inside human cells to repair, restore, or reduce proteins to treat diseases.

RNA medicines provide advantages over other types of medicines, including the ability to:

  • Avoid risk of permanent off-target genetic changes associated with DNA-targeted approaches
  • Modulate the enormous transcriptional diversity of cells
  • Address diseases that have historically been difficult to treat with small molecules or biologics
  • Access a variety of tissue types or cell types throughout the body
  • Modulate the frequency of dosing to ensure broad distribution within tissues over time
  • Leverage well-established industry manufacturing processes and regulatory, access, and reimbursement pathways
image: scientist writing on board

what’s possible

Our scientific approach is based on the recognition that the biological machinery necessary to address human diseases already exists in our cells and can be harnessed for therapeutic purposes with the right tools.

We have built the most versatile platform to develop RNA medicines in the industry, with multiple means of repairing, restoring, or reducing proteins depending on the unique biology of a given disease target and treatment goals. This core capability sets us apart from other companies and enables us to pursue the optimal treatment approach for each disease.

Our modalities

person with blue glove testing vile

Pioneering Best-in-Class Chemistry

Since our founding, we have deftly challenged convention related to oligonucleotide chemistry. This led us to discover and develop several proprietary, novel innovations that enable us to optimize the pharmacological properties of our molecules, thereby enhancing potency, distribution, and durability in the body.

Due to these chemistry modifications, we can avoid the use of complex delivery vehicles, such as lipid nanoparticles and viruses. Instead, our candidates for liver diseases use clinically proven N-acetylgalactosamine (GalNAc)-conjugates or are freely taken up in a variety of other cell types, including neurons in the central nervous system, muscle cells, and more.

Wave maintains strong and broad intellectual property on our novel chemistry modifications, including stereochemistry, phosphoryl guanidine-containing backbone linkages, and others.

Click below to learn about some of our proprietary chemistry modifications


  • Our foundational technology was built on the recognition that significant opportunity exists to tune the pharmacological properties of oligonucleotide therapeutics by leveraging three key features of these molecules: sequence, chemistry, and stereochemistry.
  • Our unique ability to control stereochemistry throughout each oligonucleotide provides the resolution necessary to optimize pharmacological profiles and develop and manufacture stereopure oligonucleotides.
  • Stereopure oligonucleotides are comprised of molecules with atoms precisely and purposefully arranged in three-dimensional orientations at each linkage. These differ from the mixture-based oligonucleotides currently on the market or in development by others.

PN chemistry

  • Phosphoryl guanidine-containing backbone linkages, or “PN chemistry,” are neutrally charged linkages that help stabilize our oligonucleotides.
  • With more stability, oligonucleotides containing PN chemistry demonstrate substantial improvements in potency, distribution and durability compared with more traditional phosphorothioate (PS) or phosphodiester (PO) linkages.
  • These effects are particularly remarkable in stereopure oligonucleotides.